The selected subgraph patterns can potentially be redundant or irrelevant, thereby compromising the effects of side view data.
However, because of the many adverse events in the use of tamoxifen, some of which have contributed to significant morbidity and mortality, drug modification which has resulted in fewer incidences of adverse events without compromising the therapeutic effect for breast cancer prevention may face an easier road to acceptance.
This might allow reduction in the IR dose, without compromising the antitumor effect.
Moreover, Prinseq cannot provide accurate and detailed information of the contaminating species, thus compromising the QC effect on downstream analysis.
Reduction of dose and treatment duration has been shown to decrease these complications without compromising the antitumor effect [ 23].
This study indicates that cilastatin protects against vancomycin-induced proximal tubule apoptosis and increases cell viability, without compromising the antimicrobial effect of vancomycin.
Recent clinical trials, using DFMO in combination with the trypanocidal agent nifurtimox, demonstrated that the course of DFMO treatment could be shortened and simplified (with infusion every 12 h for 7 days, instead of every 6 h for 14 days) without compromising the antiparasitic effect of DFMO [ 32].
11 Moreover, attenuation of Ras-GRF1 and ERK signaling in the NHP model of PD results in a strong reduction in dyskinetic symptoms without compromising the antiparkinsonian effect of l-DOPA, providing a more clinically valuable approach via targeting Ras-ERK, which may ameliorate this pathological condition.
We had found that PME has antiestrogenic effect in the mammary gland, without compromising the beneficial effects of estrogen in the cardiovascular and skeletal system and had no estrogenicity in the uterus [ 53].
However, this would inevitably have introduced a bias by compromising the oddball-effect (i.e. abnormal conditions).
