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Destroying free radicals may help fight cancer, heart diseases, stroke and other immune compromising diseases [12, 13].
An early and adequate prognosis and risk assessment facilitates an optimized care of patients with severe infections and other compromising diseases.
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Oxidative stress can trigger parenchyma cells to undergo regulated necrosis [ 55], leading to tissue damage and organ dysfunction, eventually compromising disease tolerance to infection [ 12].
Cattle were retained for seven years post inoculation or culled when they developed BSE signs or other untreatable or welfare compromising disease.
More generally, conditions that allow high parasite loads with a reduced effect on host health could result in poorer detection of infection, compromising disease control efforts [ 14].
Female cattle were kept until development of unequivocal signs of a neurological disease consistent with BSE or signs of any other untreatable or welfare compromising disease; surviving dosed cows were culled at 88 mpi together with age-matched control cows.
Clinical trials have focused on decreasing toxicities of overly intensive treatment (without compromising disease control) in good-risk patients, and on identifying poor-risk patients who could benefit from treatment intensification (Table 1).
An individual risk assessment is essential, taking the primary disease with the medication and further wound-healing-compromising diseases and medications into account.
Reactivation of TB is typically associated with an age-related decline in immunity, immunosuppression or immune-compromising diseases such as HIV.
Vaccination represents a potential key primary prevention for diverse age and target groups including adults and the elderly, adolescents, pregnant women, people suffering from chronic and immune-compromising diseases (Fig 2).
Four had an immune-compromising disease (diabetes, corticosteroid therapy).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com