Sentence examples for compromised targeting from inspiring English sources

However, these highly engineered liposomes generate new problems, such as accelerated clearance from circulation, compromised targeting owing to non-specific serum protein binding, and hindered tumor penetration.

Disruption of bundle formation, either through treatment with Latrunculin A (LatA) or following expression of a dominant-negative form of mDia1, led to compromised targeting of the secretory process.

The reactivation of TEs is often coupled with disruption of chromatin-based epigenetic controlling mechanisms in the hybrid genome, like loss or re-patterning of cytosine methylation and compromised targeting by small interference (si) RNAs [ 9- 11].

Finally, we need to ask: If companies that use software exploits to compromise targets in the public interest come to learn that other, less savory individuals are using the same exploits for ignoble purposes, do they have an obligation to disclose the problem?

We emphasize that parotid dose reduction does not compromise target coverage as there was no difference in PTV coverage between the two groups.

For delivery purposes the nNP-ricin vector must not heavily compromise target cell protein synthesis, as such, no less than 75% protein synthesis must still occur in the MC57 target cells.

Kirk directs the Enterprise into the nearby Mutara Nebula; static discharges inside the nebula render shields useless and compromise targeting systems, making the Enterprise and the Reliant evenly matched.

Despite improved CXCR4 affinity, [68Ga]NOTA-pentixafor showed severely compromised CXCR4 targeting efficiency compared to the parent compound [68Ga]pentixafor, both in vitro and in vivo.

Similarly, depletion of Arf79F or βCOP compromised LD targeting of the triglyceride-synthesis enzyme DGAT2.

Problems include ballistic targeting compromised by respiratory movements, poor tolerance of neighboring healthy tissues and difficult dosimetry due to the heterogeneous nature of the thoracic tissues.

The assessment was compromised by ineffective targeting of children at risk and uneven programme delivery.