Sentence examples for compromised substrates from inspiring English sources

CALR deletion leads to impaired system wide quality control of newly synthesized glycoproteins, as well as global accumulation of conformationally compromised substrates and general abrogation of calcium-dependent protein folding processes [ 25– 27].

Our current results showed that several Pro substitutions in the MRE β-loop exerted opposite effects, that is, they compromised substrate binding and cleavage.

Other mechanisms could be involved, especially perivascular edema that can compromise substrate and oxygen delivery.

However, in E. coli during the evolutionary process, the enzyme has probably compromised its substrate specificity and has also acquired self as well as promiscuous biotinylation.

However, it is important to note that while F-FHBG can be used to image the CNS in situations where the BBB is compromised, this substrate cannot cross an intact BBB and thus cannot detect labeled cells present in healthy brain tissue [ 52].

The disruption of potential hydrogen bonding interactions by substitution of a hydroxyl group with a fluorine further compromises these substrate analogues.

In addition, the introduction of arginine modifications can either create or compromise a substrate recognition site for other histone-modifying enzymes even spanning different histone tails.

Results obtained with constitutively active Raf mutants has been questioned, since the lack of the regulatory domains in the Raf mutants may compromise the substrate specificity and the dynamic regulation of activity [ 9].

This V246M mutant mimic also displays a significantly higher K m for the acyl-CoA thioester substrate, suggesting that binding of this substrate is compromised at least subtly in this mutant.

Therefore, through decreased proteasome function in ubp14∆ and pad1-1 (rpn11-ts) mutants, we predict that the degradation of APC/C substrates is compromised, further exacerbating the cut9-665 temperature sensitive phenotype.

Consistent with contacts made with PP1, the RE; KE double mutant was compromised ∼twofold as a substrate of the binary complex but more than 10-fold as a substrate of the ternary complex.