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Although the α-glucan capsule is shed readily in detergent-containing liquid cultures, a knockout of GlgA compromised persistence of tubercle bacilli in a mouse infection model, suggesting that persistence requires an intact capsule.
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Very weak connectivity should compromise persistence because 'rescues' are less likely.
Very strong connectivity should compromise persistence because the dynamics of subpopulations become synchronized.
"Negotiations will be hard on all sides, and a constructive spirit, willingness to compromise and persistence will be needed to reach a lasting settlement," the official added.
The immunogenicity of nonhuman scFv could cause host rejection against CAR T cells and compromise their persistence and efficacy.
From a longer term perspective, we are uncertain whether extinction of local sea/river-type populations would necessarily compromise the persistence or evolution of sockeye salmon during future glaciations (if these occur despite global warming) more than would the extinction of lake-type populations.
Although he was deported to the more remote area of Nicomedia because of these virulent attacks, Becchus refused to compromise, and his persistence helped bring about Gregory's deposition in 1289.
Of note, treatment of IP3R(1,3 -silenced DCs with the ROCK inhibitor Y27632 did not further compromise their migration persistence, indicating that this kinase does not compensate the lack of MLCK activity in these cells (PS and AMLD, unpublished results).
For benthic organisms, compromised larval performance has implications for recruitment success and persistence of adult populations [1], [9].
3– 6 However, their effectiveness in clinical practice is often compromised by poor adherence to dosing instructions and poor persistence with treatment.
However, the persistence and health of amphibian populations are likely to be compromised by the escalating use of pesticides and other agricultural chemicals.
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