However, increasing PEG content to ~ 12 mol% compromised BA loading and vaginal distribution, suggesting that PEG content must be optimized to maintain drug loading and stability.
Interestingly, c-ETS2 overexpression led to increased BrdU incorporation in the S phase cells while its down-regulation by RNA interference compromised the loading of pre-replicative complex at the origin.
In this study, we found that the ultimate compressive strength of cement specimens was significantly compromised by loading with liquid antibiotics (p < 0.05).
Whilst the variants shifted 1 and 2 bases (CODEMIRs 11 and 12) would be predicted to have compromised strand loading due to the introduction of a G C base pair close to the 5' end of the guide strand, the variant shifted 3 bases (CODEMIR-13) would be predicted to retain a strong loading bias towards the guide strand.
Grass-cutting ants offer a unique opportunity to investigate whether workers use flexible cutting rules and compromise their load delivery for a faster return to the nest, because changes in load-size determination (fragment length) are not associated with additional costs or energy savings, as outlined above [23].
As the price does not change with the load, its performance may be compromised if the load varies, whereas our approach is adaptive and should be able to deal with varying load.
A possible explanation is that lower stability and disturbance of local conformation of the pri2 mutant proteins compromise loading of the pol-prim complex onto replication origins.
In contrast the alternative design of the SIS sling showed a higher textile porosity, which is not compromised at tensile load.
An intriguing possibility is that the expanded GAA triplet-repeat sequence, possibly via formation of a non-B DNA structure [3], [16], [39], may compromise the loading, binding, or stability of cohesin and thereby promote CTCF displacement.
A minor but consistent positive effect was observed (Fig. 2b), suggesting that storing stock protein samples in a glycerol-based buffer is appropriate for the purposes of electroporation, and will not compromise cell loading.
