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We found that unlike other RITs, deletion of domain II from LMB-2 severely compromised its activity.
awamori compromised its activity on cellulose.
It is evident that the Leu69Ala substitution in TH-ProCLV3Leu69Ala has partially compromised its activity in SAMs.
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Therefore, once ACF is accumulated in the nucleus, the effective concentration of ACF outside the cell may not compromise its activity.
Altogether, our data show that a GFP tag in the C-terminus of EGFR does not compromise its activity in vivo.
Daptomycin showed excellent in vitro activity against staphylococci and enterococci collected in European medical centers in 2005 and resistance to oxacillin, vancomycin or quinupristin/dalfopristin did not compromise its activity overall against these pathogens.
Taken together, these results indicate that by simply conjugating targeting ligands on the surface of the MCNPs, we can adopt a facile approach for conferring tumor targeting capability to the ATAP moieties without making any structural modifications to ATAP, which can compromise its activity.
The oligomerization of AβMRF compromised its translational termination activity causing a more frequent readthrough of the ade1-14's premature stop codon, which was easily scored by yeast growth (Fig. 1).
Because ERK activation has been shown to be essential for mitogenic signals and to promote cancer proliferation and metastasis in various types of cancer including RCC (Campbell et al, 2009), WP1066-induced activation of ERK might compromise its antitumour activity.
In DNA-PKcs, charge-reversal amino-acid substitutions targeting the PRD also compromise its kinase activity (Mordes et al, 2008).
The CpG sites at the regulatory region of POLG in the retina are hypermethylated, and this possibly compromises its transcriptional activity [ 52].
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CEO of Professional Science Editing for Scientists @ prosciediting.com