Sentence examples for compromised interactions from inspiring English sources

In contrast, with CASQ2R33Q mutation, compromised interactions between RyR2 and calsequestrin markedly lower the threshold of luminal Ca2+ concentrations for the termination of SR Ca2+ release.

In these experiments, phosphopeptides in which each of the three aspartate residues were individually substituted by alanine all failed to show any significant quantifiable binding, and replacement of pSer491 with Glu as a phosphopeptide mimic also severely compromised interactions.

In the first-generation RSs, however, these interactions with Tyr would not be expected to be preserved given that most have either Gly at position 158 (which would abolish important interactions with this side chain) or compromised interactions with the amino acid substrate backbone.

In previous studies, it has been shown that compromised interactions between the fusion peptide and Asp-112 destabilized the protein, increased the fusion pH, and accelerated the kinetics of membrane fusion.

Hence, the residual rMT formation and affinity to the SPB seen in hrs1.D7 cells may be afforded by Hrs1-Kms2 intoracompensatecompensate for compromised interactions with Kms1 and Alp4.

The RPGR H98Q and F130C mutants exhibit compromised interaction with RPGRIP1 (61), suggesting that RPGR RPGRIP1 interaction may be an important determinant of RPGR activity.

Possible reasons for the dramatic effect of the serine substitution at residue 68 of gpD include interference in gpD trimerization and/or compromised interaction with gpE hexamers, although previous findings indicate that the N-terminus is located closer to the threefold axis of the gpD trimer (Yang et al. 2000) and may be involved with interacting with gpE.

However, this often compromises interactions with its molecular target (Weiss, 1992).

Additional removal of the poorly conserved N-terminal region did not detectably compromise interactions (Table S1).

It has been suggested that alterations in lamin A/C might compromise interactions between the nucleus and cytoskeleton involved in nuclear positioning (Mejat et al. 2009; Mattioli et al. 2011).

The goal, both reflexive and pragmatic, is for students to become independent thinkers and autonomous subjects whose independence and autonomy are not compromised by interaction with others.