Finally, with a disease-specific mortality of less than 1%, survival was not compromised in our study.
Further potential benefit from system usage was compromised in this study due to many reasons: unavailability of computers, poor Internet access, and slow network connections frequently prevented subjects from accessing the DDSS.
Although 6-minute walk distance and Physical Component Summary (PCS) of the 36-Item Short-Form Health Survey (SF-36) were clearly compromised in this study and improved over time, these may not have been sensitive or specific metrics to capture the subtlety of improvement in muscle weakness in this more resilient patient sample.
Lastly, by overexpression of PTEN or Ricin, the mTOR pathway function is compromised; in mammalian studies, p53 is both an upstream inhibitor and downstream target of the mTOR signalling, which controls cellular and systemic response during development and stress [ 57].
Other factors that may influence PRS performance may be the heterogeneity of the phenotype, which paradoxically is often compromised in GWAS studies in the need for large sample sizes and better prediction power.
We found a strong accord between our macro-scaled ATSR product and the Canadian fire database, even in the northern boreal forests where detection of fire can be compromised in finer-scaled studies [10].
Similarly, even if the assumption of low frequency of significant interactions may become compromised in more targeted studies, such as the one of St Onge et al, this should not have a major effect on the results as the strongest genetic interaction pairs are effectively filtered out in the sequential estimation process.
In line with this, expression of Larg, encoding a protein that activates RhoA, was reported to be compromised in FXS in an earlier study [ 10].
The results show that carer well-being is compromised, in line with previous studies.
Although it is generally suspected that walking capacity is compromised in obese COPD patients, this study is the first to systematically investigate the impact of obesity on specific exercise modalities.
