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Although the exact cause of death is not known for Asxl2−/− animals, heart enlargement in these animals may have compromised heart function and contributed to the animals' deteriorating health.
This intrinsic antioxidant property of AZL may provide a promising advantage over other calcium channel blockers in the management of compromised heart function especially under diabetes.
To evaluate the effect of levosimendan on postoperative renal function in patients with compromised heart function undergoing on-pump coronary artery bypass graft surgery.
Such increases may not be tolerated by spontaneously breathing patients with compromised heart function [ 7].
Overall, these observations may explain the compromised heart function in mice when cardiomyocytes are deficient in vinculin [ 46].
Conversely, impaired renal function has a significant impact on the prognosis of patients with compromised heart function.
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Acute ethanol treatment led to compromised heart functions with decreased fractional shortening, peak shortening, and an intracellular Ca2+ rise in mouse cardiomyocytes.
These changes are likely to compromise heart function and could therefore also affect the graft response after heart transplantation.
Other possible causes of this fish death, such as Na+ K+ ATPase inhibition [ 24] and tissue hypoxia, which compromises heart function, need to be examined.
However, heterozygous dOpa1mutation caused a significant increase in heart failure when compared to wild-type controls and this was true for both males and females (Figure 6, p = 1.63e-05), suggesting heterozygous dOpa1mutations compromise heart function in the flies and decrease their ability to tolerate arrhythmia by stress.
The joint response of E es, rvf and R sys attempts to prevent a leftward shift in the intraventricular septum wall, which would reduce the stressed volume in the left ventricle and therefore compromise left heart function.
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