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The IUGR placenta exhibits compromised growth of villous trees, a smaller intervillous space and a lower diffusive conductance.
By contrast we find that expressing a dominantly active Rab11 mutant led to compromised growth in mice.
Furthermore, viruses carrying R294K exhibit compromised growth and fitness in vitro and were found to revert back to wild-type NA (R294) following multiple cycles of replication.
An analogous PD mutation, R103W in yeast Ssc1, results in conditional phenotype with highly compromised growth at permissive and inviability at non-permissive temperatures.
As shown in Fig. 5E, R103W was extremely sensitive to oxidative stress and was found to have a severely compromised growth phenotype in the minimal media containing 1 m m H2O2.
In each case, the Malaysian allele of the respective gene compromised growth in high-iron conditions, mirroring the known effects of engineered null mutations at these loci (Li et al. 2001; L. Li et al. 2008).
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The French government this week announced new austerity measures that are likely to compromise growth, just as they have in the UK.
The risks often exceed those faced by adults who get carried away with a chosen sport because young athletes are still growing mentally and physically, and so are vulnerable to certain injuries, some of which can compromise growth.
BMP2-iPSC-MSCs did not compromise growth kinetics and cell cycle stages compared to iPSC-MSCs.
We show here that increased production of ROS can also compromise growth in cells not devoid of antioxidant activities.
Fetal growth restriction compromises growth of nutrient storage organs such as adipose tissue and this is compensated by adaptive metabolic changes such as greater insulin sensitivity to favour energy efficiency and utilization of alternate source of substrates.
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