Sentence examples for compromised functions from inspiring English sources

In such cases, the nuclear receptor coactivator 3 which integrates these signals [45] and regulates the white adipogenic program [46] may substitute the compromised functions according to a co-activator hypothesis [47].

Furthermore, it is proposed that astrocytes might be promising target of therapeutic intervention for Alzheimer's disease, if these compromised functions can be normalized with pharmacological agents that are specifically designed to return astrocytes to a quiescent phenotype or supplement factors which activated astrocytes lack to produce.

Thus, a loss of LRP5 resulted in compromised functions of retinal interneurons.

It is primarily the compromised functions that occur when lean tissue is mobilised that ultimately leads to death when starving.

Brc1 is not essential for cell viability, but it is required in strains with compromised functions of the Smc5−Smc6 complex (Morikawa et al. 2004; Pebernard et al. 2004; Verkade et al. 1999).

The immunological investigations of the astronauts recorded several dysregulations, such as the altered production of cytokines [ 2], enhanced sympathetic neuroimmune responses [ 8], compromised functions of monocytes [ 9, 10], suppressed cytotoxicity of T-cells and Natural Killer (NK) cells [ 11], and reduced phagocytic capabilities of neutrophils [ 12].

These data highlight the need for a range of functional studies to be performed in order to identify variants with partially compromised function.

Routine culture of primary hepatocytes is difficult and cumbersome due to their ability to develop compromised function.

The mutation can cause loss of function of the protein by dominant negative effects, or reduced or compromised functioning.

However, it is not known which of these proteins shows compromised function that may play a key pathogenic role.

Indeed, perhaps compromised function of the proteasome and autophagy arising from such intermediates may be the principal toxic insult to the cell (see below).