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In this scenario, which remains to be tested, complex I deficiency could be explained by decreased expression levels of correctly spliced NUBPL, in combination with mildly compromised functionality due to the missense mutation.
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Critically, its designers were also unafraid to compromise functionality in pursuit of this concept.
Further, to achieve covalent linking, cargoes are chemically modified, which may compromise functionality.
Sequences with functional activity are subject to selective pressures that prevent the fixation of mutations that would compromise functionality.
The molecular functionality of such structures can no longer be assumed to be optimal, as slightly deleterious mutations may have compromised functional integrity [ 10, 99- 102].
Describing the plane, already more than 20 years old, as "awe inspiring", he extolled its style and beauty, noting that this had never compromised its functionality.
Here, using stable transfected SH-SY5Y cells overexpressing APP751wt (SY5Y-APP) we demonstrated that the expression of an unfolded p53 conformation compromised neuronal functionality.
The formulation of micronutrients and nutraceuticals in the design of functional foods and beverages brings enormous technological challenges because often this can compromise product functionality.
Invasive species disrupt landscape patterns and compromise the functionality of ecosystem processes.
The incidence of complications in need of a complete laryngectomy does not compromise the functionality of this technique.
This degradation mechanism does not compromise the functionality of the device which is found sufficiently robust for multiple tests at high temperature.
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