Sentence examples for compromised fitness from inspiring English sources

However, the R220G mutation, which resides in the proximity of the HA receptor binding domain, might also contribute to compromised fitness in mice.

Indeed, we observed compromised fitness upon mutation of the tDNA upstream of ATG31, as the mutant strains under-expressed Atg31p and were defective in autophagy induction [ 30].

These studies indicate that peripheral populations may be more susceptible to the stresses imposed by climatic change due to their already compromised fitness and reduced genetic variation, especially if competition with other species limits their ability to migrate.

The basic assumption in these studies is that if a gene is important for normal growth in presence of a given stress its partial or complete loss would uncover a stress gene interaction, which can be measured as compromised fitness.

Although resistant mutants may initially emerge with compromised fitness and growth [18], mutations that compensate for this impaired fitness may arise [13], [14].

Mutation accumulation experiments have found that compensatory mutations arise in C. elegans lines with compromised fitness and that they can increase fitness rapidly [ 61].

Hence, our findings suggest a paradigm of PCIs not only as transcriptional regulators, but also as evolutionary accelerators that can facilitate intron insertion perhaps via modulation of chromatin structure [29] under environmental circumstances in which transcriptional inhibition does not compromise fitness.

Experimentally, we made the novel observation that the complete absence of SLT2 severely compromises fitness in the tetraploid state.

It is thus the essential controller of HOG pathway activity, and variations in its concentration could compromise fitness.

In animals with heterogametic sex determination, accumulation of HI genes on the sex chromosomes would compromise fitness in both sexes, given X chromosome inactivation in females.

This result suggests that readthrough of the cryptic transcript reduces Atg31p translation to a level that compromises fitness of the cells during nitrogen starvation.