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This disparity may reflect compromised fidelity of DSB repair in NBS cells rather than reduced efficacy.
Several Pol β variants with alterations in residues lining this hinge region have demonstrated compromised fidelity (16− 20).
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The results of three different types of silver nanoparticle treatment on E. coli suggested compromised replication fidelity of the risk gene [125].
In summary, the timing of suppliers' FV delivery or their lack of delivery acted as barriers for teachers' implementation and pupils' dose received and compromised intervention fidelity in the first months of the intervention year.
When an old tape machine makes pitch wobble, some people would say that compromises fidelity and would try to get rid of it.
Altogether, the results indicate that the deletion of TAE1 seems to compromise translation fidelity, providing further evidence that TAE1 affects translation.
These observations indicate that PDTC may have abnormalities in MSAC or in the attachment of kinetochores, which may compromise mitotic fidelity and contribute to chromosomal instability.
However, mutations may occur in the vector at non-desired sites during PCR amplification, which can compromise the fidelity of the approach.
Unrepaired DNA lesions are known to compromise the fidelity and/or efficiency of DNA-templated processes, including DNA replication and transcription.
The conduct of ecologically valid research in this field is reliant on the development of empirical tools that do not compromise the fidelity of the phenomenon under investigation in order to conform to the demands of traditional research paradigms.
The highly reactive OH targets DNA, attacking deoxyribose residues resulting in nicks in double-stranded DNA which can compromise chromosome fidelity and ultimately lead to cell death (Imlay, Chin and Linn 1988; Rai et al., 2001).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com