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PUFAs can play a role in both reproduction and immunity, presumably via the action of eicosanoids, and hence we propose that the significantly higher investment in reproduction observed in offspring of mothers raised on PUFA-containing food sources has compromised defence mechanisms and thus resulted in the very high infection success.
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Cosilencing of two MAPKs, MPK1 and MPK2, in tomato compromised their defence response against insect larvae compared to wild type plants.
Increased ovarian protein carbonyls were observed in offspring born to mothers UN during pregnancy and/or lactation and this was associated with peroxiredoxin 3 hyperoxidation and reduced mRNA levels; suggesting compromised antioxidant defence.
It was proposed that defective Th1 responses compromised host defence to intracellular parasitic infections, in particular.
Non-atopic eczema in childhood could be a marker of vulnerability for cervical cancer as some eczema types may indicate compromised host defence.
Patients with PAD and diabetic complications, such as neuropathy, compromised infectious defence and microcirculatory changes, have a substantially increased risk for disability, amputation and death [ 1].
The temperature-dependency of Bd infection has been demonstrated for Xenopus (Silurana) tropicalis by Ribas et al. (2009): increased infection levels at suboptimal host temperatures may be attributable to impaired antimicrobial peptide activity and compromised immune defence.
First, hospitals contain clusters of highly vulnerable patients, many of whom will have predisposing pulmonary conditions that compromise defence mechanisms in their airways.
In contrast to a suggested protective role of atopic eczema, non-atopic types such as seborrhoeic eczema may indicate compromised host defences and represent an increased risk for persistent HPV infection and cervical cancer.
Regarding the IL-22/IL22R IL-22/IL22Rantimicrobiale hypathwayzed that any alteration of IL-22R in the lungs of COPD patients may compromise innate defence mechanisms and enhance susceptibility to infections.
RSV have been shown to compromise airways defences via damage to airway epithelium and depletion of the periciliary layer (PCL) [ 11].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com