Sentence examples for compromised damage from inspiring English sources

Recently, DNA lesion-carryover into the M phase has been shown with fewer than 20 foci of γH2AX per nucleus in the ATM-mutated background after X-ray or γ-ray irradiation [12], implying that cell cycle checkpoints are bypassed under a small number of lesions with compromised damage checkpoint response.

When naturally occurring protection mechanisms, such as enzymatic and non-enzymatic ROS scavengers are compromised, damage accumulates, which then leads to apoptosis.

We next investigated whether compromised DNA damage repair in XPA mutant NSCs could be associated with decreased cellular survival.

Compromised DNA damage will likely result in accumulation of DNA lesions and eventually facilitate tumorigenesis.

The compromised DNA damage repair capacity of iPSCs should be considered when used in clinical therapy.

One major effect of mild HU treatment is the persistent DSBs that might result from compromised DNA damage repair.

Depletion of tankyrase 1 via siRNA transfection in various human cell lines resulted in increased sensitivity to IR-induced cell killing, mutagenesis and chromosome aberration, notably terminal deletion, end-points consistent with compromised DNA damage response/repair.

Increased cell proliferation, and decreased OGG1 and thus, compromised DNA damage repair potential after 7 days of E2 treatment might be the initial steps that lead to the accumulation of carcinogenic insults at later time points.

This study showed a lower proportion of compromised or damaged endocervical surgical margin in specimens resulting from SWETZ in relation to LLETZ-cone.

Candidate shared pathways include changes in hormonal milieu, inflammation, oxidative stress, DNA damage and compromised DNA repair, genetic susceptibility, decreased brain blood flow or disruption of the blood-brain barrier, direct neurotoxicity, decreased telomere length, and cell senescence.

A similar tradeoff may underlie the pattern of mortality in our experiment; metamorphosis requires high inputs of energy [41] and cannot be delayed or compromised to repair the damage caused by compensatory development when the larval habitat approaches termination.