Unfortunately, many of the current cryopreservation protocols are suboptimal resulting in poor cell recoveries and/or compromised cellular function post cryopreservation thus limiting applications.
This resulted in a decrease in cellular ATP levels consistent with compromised cellular function.
This difference in Hsp101 expression between the two CT treatments may be caused by strongly compromised cellular function at 45 °C and only partially compromised cellular function at 42 °C.
Pleiotropic effects of resistance mutations are apparent from the so-called cost of resistance in the absence of antibiotics due to the allocation of resources into antibiotic-degrading enzymes or efflux pumps, or compromised cellular functions, such as DNA or protein synthesis (Andersson and Hughes 2010).
Similarly the function of "ER stress" is shared across two processes ("Cellular compromise", "Cellular function and maintenance").
Thus, a small reduction in the efficiency of ATP synthesis could significantly compromise cellular functions, including contraction and relaxation.
Therefore, regulatory interactions between host iron homeostasis (quantity and subcellular location) and immune function are crucial, since both iron deficiency and iron excess can compromise cellular functions [ 3].
Functions assigned on a molecular and cellular level "more prominently present in (Br5 6) CPE than in (Br0 1) CPE" included: cellular compromise, cellular function and maintenance, post-translational modifications, protein folding as well as cell death and survival.
The T4 networks contained a total of 244 differentially expressed genes which were involved in pathways and functions including the Cellular Movement, Haematological System, Immune Cell Trafficking, Haematopoiesis, Tissue Development, Antigen Presentation, Cellular Compromise, Cellular Function and Maintenance and Inflammatory Response.
For example, in brain ischemia, neu-ronal cell death, cardiac dysfunction, and muscular dystrophies, excessive proteolysis of substrates by calpain, which is not the primary cause of these pathological states, further compromises cellular functions and aggravates symptoms [ 8– 13].
End stage renal disease (ESRD) is known to compromise cellular immune function, and patients on dialysis have been shown to have T cell dysfunction including abnormal IFN-gamma levels, considered to have a pivotal role in controlling latent TB infection [ 10, 11].
