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However, it cannot be ruled out that the structural defect in NBD1 of ΔF508 CFTR would confer compromised capacity of the protein to be involved in protein protein interactions and that VX-809 acts to partially overcome this structural limitation.
When patients have low baseline EPCs or a compromised capacity of EPC mobilization, they are likely to develop more severe vasoconstriction.
A wide range of life-threatening lung diseases are characterized by compromised capacity of the lung to match ventilation and perfusion.
Another assumption could be that elevated cardiac output, which has been observed in cirrhotic patients, is achieved more effectively through elevation of HR and less through elevation of stroke volume, because of the compromised capacity of the left ventricle to raise stroke volume (cirrhotic cardiomyopathy) [ 32- 34].
In conclusion, our data support a key role for increased ATGL and HSL activity in adipose tissue, leading to increased FA delivery and TG production in the liver in conjunction with a compromised capacity of the liver to compensate with increased hepatic lipolysis, FA oxidation and TG export in this model of NASH.
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Women who develop gestational diabetes are thought to have a compromised capacity to adapt to these metabolic challenges of pregnancy.
But, she said, "it does appear that the close relationship between some senior members of the Met and some sections of the media compromised the capacity of both those institutions to scrutinize the activities of the other.
This may have compromised the capacity of MSCs to offer myocardial protection.
This may have compromised the capacity of the intervention to reach patients (especially the capacity among specialized staff).
The PCOS aetiology compromised the capacity of follicular and cultured GC to consume glucose in vitro, and this metabolic effect was alleviated by pretreatment with metformin in vivo.
It caused a substantial health impact on residents in and around the city and compromised the capacity of local health services.
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