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Thus, compromised biological function of HDAC8 mutants in CdLS can result from diminished thermostability as well as compromised catalytic activity.
Populations with preexisting disease could be more sensitive to exposures that affect already compromised biological function: Exposure to irritant gases and vapors in asthmatics or patient with cardiac or pulmonary disease, for example, would be of greater concern than in otherwise healthy individuals (NRC 2001).
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Our results suggest that interference can severely compromise biological functions in an adapting population, which sets viability limits on adaptive evolution under linkage.
As shown in Figure 4, low values of the degree of adaptation α are observed over large regions of the evolutionary parameters γ and L. This indicates that a substantial part of the genome can be degraded to a nearly random state, implying that interference effects can compromise biological functions (see Discussion).
Tissue hypoxia results from an inadequate supply of oxygen (O2) that compromises biological functions.
However, high-density additives can interfere with droplet generation and compromise biological activity.
But the SOA Assessment criteria fail to integrate the principal element of the AOP - that perturbations of biological pathways must be sufficiently large to overcome adaptive responses before biological function is compromised.
This compromises the cells biological functions with a concomitant increase in compensatory glycolysis [156].
They provide a compromise between biomechanical and biological function for the healing process, modulating host cell response and, consequently, accelerating the biology of tissue repair and integration with adjacent cartilage [ 6, 7].
Yet, genes to which no biological function has been assigned compromise the usability of these data.
Environmentally triggered illnesses in humans arise when normal biological functions become compromised by stressors.
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