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Equivalent levels of Prdx6 in Cftr+/+ and Cftr−/− lung after exposure to PQ, together with a diminished capacity to eliminate PC-OOH in Cftr−/− mice suggest a compromised antioxidant function of Prdx6 that could be associated with post-translational modifications.
Failure to control the oxidation state of proteins can arise from mitochondrial disease and compromised antioxidant function.
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NRF2 can regulate mitochondrial antioxidant function [55].
To investigate changes in endogenous antioxidant function age, we measured total antioxidant capacity in-situ using the Trolox assay.
Basal p53 level has indeed an antioxidant function.
This intrinsic antioxidant property of AZL may provide a promising advantage over other calcium channel blockers in the management of compromised heart function especially under diabetes.
These people have compromised executive function.
However, compromised spleen function has not been reported after PRRT.
Thus, compromised biological function of HDAC8 mutants in CdLS can result from diminished thermostability as well as compromised catalytic activity.
This difference in Hsp101 expression between the two CT treatments may be caused by strongly compromised cellular function at 45 °C and only partially compromised cellular function at 42 °C.
A recent study has indicated compromised p53 function in aging mouse tissues [ 20].
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