As shown in Electronic Supplementary Material Fig. S3, recovery of the analytes was within ±20% for all the concentrations tested, so direct injection of quenched incubation samples did not compromise analytical performance.
Based on these results, we recommend that global shotgun lipidomic experiments employing chemical sulfation of sterols use a specific sequence of MS analyses where the analysis of sulfated samples is scheduled at the end of all other analyses in order not to compromise analytical sensitivity (Fig. 2).
The authors found an error in the definition of Ulhi that compromises the analytical load sharing and mesh stiffness model when it is applied to helical gears.
Simultaneous measure of eight vitamin D analogues does not compromise the analytical capability of the assay to quantify the commonly used biomarker (25OHD) for vitamin D status.
The results show that the new assay's ability to quantify 25OHD levels is comparable to other LC-MS/MS methods represented in the DEQAS data, thus the simultaneous measures of eight analogues does not compromise its analytical capability for assessing the commonly used biomarker (25OHD) for vitamin D status.
A series of sensitivity analyses established that other potential confounders, including age, geography, and viral subtypes, did not obscure or compromise our analytical approaches.
The best compromise of analytical conditions for the simultaneous determination of analytes from spiked artificial saliva were found to be: pH (3), adsorption time (30 min), activated carbon amount (1.8 g L−1) and elution solvent (chloroform).
The best compromise of analytical conditions for the simultaneous determination of analyte from spiked artificial sweat was found to be: pH (3.1), activated carbon amount (1.4 g L−1), adsorption time (55 min) and elution solvent (chloroform).
However, if the integrity of the specimen was compromised before its analysis, the analytical measures, although valid, could lead to erroneous interpretations.
A compromise between analytical signal and sample frequency was established by choosing a working flow-rate of 0.25 mL/min.
