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These results suggest that EA, by inhibition of the Wnt/β-catenin pathway, compromised an important survival signal in CLL cells and increased their vulnerability to cell killing induced by chemotherapeutic agents.
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This suggested that the development/growth of LplA1 null-mutants was severely compromised implying an important role for P. berghei during blood stage development.
"These seemingly innocuous chemicals are harmful in an unexpected way," says Luckenbach. "They have shown that [musks] can compromise a really important defense system," says Tvrtko Smital, a molecular ecotoxicologist at the Rudjer Boskovic Institute in Zagreb, Croatia.
Though the letter called the debt ceiling compromise an "important first step," only three of the signatories voted for it: Representatives Jim Cooper of Tennessee, Michael H. Michaud of Maine and Henry Cuellar of Texas.
The results described here indicate that dysfunction of human condensin both compromises an important controlling mechanism (correction of syntelic and merotelic attachments) and leads to chromosome damage (breaks) and nondisjunction.
In contrast to the impasse over energy, we may be seeing some compromise on an important healthcare issue -- prescription drug importation.
Activation of K+ channels, in situations in which repolarizing K+ currents are compromised, could be an important protective mechanism against lethal arrhythmias.
Compromise is an important part of relationships, Forbes stresses; there are riches to be mined.
But the government said the compromise was an important step in reversing Indonesia's record of unchecked clearing of tropical forests.
The decision to seek a compromise marked an important victory for the soft Brexit/Remainer/ realist" Tory rebels, who have been promised an amendment giving them most of what they want.
When they see their parents co-parenting and working through the issues in a divorce, children learn that compromise is an important and effective skill.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com