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(Justice Ruth Bader Ginsburg's devastating dissenting opinion last week read to me as if major portions had been written back in 2009, rendered unnecessary by the compromise outcome then, but saved for the day that she knew was coming).
This indicates that omission of chemotherapy in these patients may not compromise outcome.
There is controversy regarding the optimal time of intervention, with some authorities recommending early intervention [ 46, 47] and others suggesting that late augmentation does not compromise outcome [ 23, 48].
Cross-trial comparisons between Vogel et al.'s study [ 8] and the pivotal phase III study [ 5] suggest that the use of herceptin as monotherapy in FISH-positive patients rather than in combination may not ultimately compromise outcome.
Concerns that this might compromise outcome could be off-set by the fact that actinomycin-D produces a response rate of 38%, which is greater than that of bleomycin (Early and Albert, 1976).
40– 43 Furthermore, secondary prophylaxis is warranted in patients who have developed febrile neutropenia with previous cycles of chemotherapy, particularly in the curative intent setting of (neo)adjuvant therapy where dose reduction may compromise outcome.
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Overall, reduced availability of fungicidal drugs continues to compromise outcomes in high-burden countries.
Although the sample size was too small to draw conclusions, ovarian preservation did not seem to compromise outcomes.
Such plots identify studies in the appropriate quadrant (i.e. those that reduce costs without compromising outcomes) and those in problematic quadrants (i.e. those that reduce costs but also compromise outcomes, or those that compromise both outcomes and costs).
Through education and outreach a majority of good-prognosis patients can be persuaded to accept SET (Ryan et al., 2007) but many are reluctant to compromise outcomes.
While health outcome data are certainly important, and readily measurable, outcomes on their own do not provide information about the factors that may hinder optimal care delivery and thereby compromise outcomes [ 11, 12].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com