Sentence examples for compromise of specificity from inspiring English sources

The enrichment analysis was performed on the third GO level, because this gave the best compromise of specificity and coverage of the gene list.

The effect is more prominent in detection of CIN2 and CIN3 than of CA. A benefit of increasing sensitivity with less compromise of specificity was found when HPV16/18 was added to methylated PCDHA4, but not to the methylated PCDHA13 or the combination of two PCDHA@ members.

Receiver operating characteristic (ROC) curve analyses indicated that cut-off values for CD28% = 82 seemed to provide the best compromise of optimal specificity (the most important consideration) and sensitivity for these major, adverse clinical events.

Similarly, compromise of the specificity of the SIT in PTB-vaccinated deer has also been reported [ 35, 36].

However, the results showed serious compromise of the specificity of the SIT in vaccinated animals prior to challenge (4 of 4 false-positive reactors), which completely disappeared when using the CIT.

According to a multicenter study, which used a sensitive immunochemiluminescent two-site assay, this cut-point provides the best compromise in terms of specificity and sensitivity for the diagnosis of adult GH deficiency through the GHRH-arginine test, thus minimizing the misclassification of multiple pituitary hormone deficiencies and control subjects [ 103].

DOI: http://dx.doi.org/10.7554/eLife.01775.006 To ensure that the use of the three-base alphabet did not compromise the specificity of probe-target hybridization, we calculated the textual complexity of randomly picked three-letter 19-mers using the algorithm of Lempel and Ziv (Ziv and Lempel, 1976; Kaspar and Schuster, 1987; Orlov and Potapov, 2004).

While the TcF43 and TcF26 antigens enhanced detection and strength of signal, they did not compromise the specificity of detection compared to that obtained with TcF.

Therefore, co-morbidities appear to compromise the specificity of the OHS in evaluating disability resulting from hip symptoms, although joint specific questionnaires are designed to exclude the effects of co-morbidities.

Several Phase III trials of DNA methyltransferase inhibitors have been completed successfully, but the efficacy of these compounds appears to be compromised by their lack of specificity.

However, the diagnosis of bacterial pneumonia is usually compromised by the lack of specificity of respiratory symptoms, which are commonly shared with other conditions that cause respiratory distress in children, many associated with high case fatality rates.