Sentence examples for compromise of efficacy from inspiring English sources

Nonetheless, we have previously reported that tolerability is improved when combination therapy is done in the context of lower doses of medication, without apparent compromise of efficacy [21, 22].

With that said, based on our analysis, an IGF-I level around the mean for the population rather than at the upper limit of normal would seem to be a reasonable approach in terms of cost-effectiveness and more prudent in terms of safety, without incurring any compromise of efficacy, especially for patients with GHD.

Keeping in mind that the cumulative dose of oxaliplatin administered to patients is the key factor of oxaliplatin-related adverse events, we herein investigated whether ursolic acid could enable a suboptimal use of oxaliplatin without compromise of its efficacy.

How to prevent chemoresistance to TMZ and reduce the doses of TMZ and thus its toxicities without compromise of its efficacy?

Well-designed clinical trials are required to provide convincing evidence showing that inhibition of MGMT is clinically beneficial for patients with gliomas by preventing chemoresistance to TMZ and reducing the doses of TMZ and thus its toxicities without compromise of its efficacy.

However, the accumulating of mutations compromise the efficacy of NA inhibitors.

Although not life threatening, HFS may give cause for capecitabine dose delay, reduction or discontinuation, with a theoretical concern regarding compromise of potential overall efficacy of the planned chemotherapy.

Our results suggest that mechanical compression of tumors may compromise the efficacy of chemotherapeutic agents.

Such differences in the relative regional incidence of serotypes could compromise the efficacy of vaccine.

The BXB-ER induced epigenetic changes also result in modifications of chromosome structure and compromise the efficacy of metaphase chromosome formation (Fig. 2D/E).

In addition, a recent study also showed that embryos reconstructed by MRT still show levels of heteroplasmy, which might impact the stability of the mtDNA genotype and compromise the efficacy of mitochondrial replacement (Yamada et al., 2016).