Sentence examples for compromise its activity from inspiring English sources
Therefore, once ACF is accumulated in the nucleus, the effective concentration of ACF outside the cell may not compromise its activity.
Altogether, our data show that a GFP tag in the C-terminus of EGFR does not compromise its activity in vivo.
Daptomycin showed excellent in vitro activity against staphylococci and enterococci collected in European medical centers in 2005 and resistance to oxacillin, vancomycin or quinupristin/dalfopristin did not compromise its activity overall against these pathogens.
Taken together, these results indicate that by simply conjugating targeting ligands on the surface of the MCNPs, we can adopt a facile approach for conferring tumor targeting capability to the ATAP moieties without making any structural modifications to ATAP, which can compromise its activity.
Because ERK activation has been shown to be essential for mitogenic signals and to promote cancer proliferation and metastasis in various types of cancer including RCC (Campbell et al, 2009), WP1066-induced activation of ERK might compromise its antitumour activity.
In DNA-PKcs, charge-reversal amino-acid substitutions targeting the PRD also compromise its kinase activity (Mordes et al, 2008).
As shown above, the ectopic localization in the ER of the BirA enzyme did not compromise its enzymatic activity, allowing biotinylation of both secretory and membrane proteins.
An important requirement for protein immobilization is that the matrix should provide a biocompatible and inert environment, i.e. it should not interfere with the native structure of the protein, which would thereby compromise its biological activity.
