Sentence examples for compromise interactions from inspiring English sources

Additional removal of the poorly conserved N-terminal region did not detectably compromise interactions (Table S1).

It has been suggested that alterations in lamin A/C might compromise interactions between the nucleus and cytoskeleton involved in nuclear positioning (Mejat et al. 2009; Mattioli et al. 2011).

However, this often compromises interactions with its molecular target (Weiss, 1992).

In contrast, with CASQ2R33Q mutation, compromised interactions between RyR2 and calsequestrin markedly lower the threshold of luminal Ca2+ concentrations for the termination of SR Ca2+ release.

In these experiments, phosphopeptides in which each of the three aspartate residues were individually substituted by alanine all failed to show any significant quantifiable binding, and replacement of pSer491 with Glu as a phosphopeptide mimic also severely compromised interactions.

In the first-generation RSs, however, these interactions with Tyr would not be expected to be preserved given that most have either Gly at position 158 (which would abolish important interactions with this side chain) or compromised interactions with the amino acid substrate backbone.

The RPGR H98Q and F130C mutants exhibit compromised interaction with RPGRIP1 (61), suggesting that RPGR RPGRIP1 interaction may be an important determinant of RPGR activity.

Possible reasons for the dramatic effect of the serine substitution at residue 68 of gpD include interference in gpD trimerization and/or compromised interaction with gpE hexamers, although previous findings indicate that the N-terminus is located closer to the threefold axis of the gpD trimer (Yang et al. 2000) and may be involved with interacting with gpE.

The significance of the KCNQ1 and KCNE1 C-terminal regions warrants more detailed studies into how they interact structurally, and how disease-causing mutations compromise these interactions.

Specifically, the most severe mutant Arg975Trp is associated with both dilated (DCM) and hypertrophic (HCM) cardiomyopathies in man where it disrupts the organization of intercalated discs, results in a pI drop of about 1.4 pH units for residues 966 983, augments cross-linking of actin filaments [8], and may compromise the interactions of metavinculin with its partners, including vinculin [9].

As an example, Y143C/H/R substitutions have been shown to have the least effects on dissociation of dolutegravir, but compromise the interactions between integrase enzyme and raltegravir.