Sentence examples for compromise function from inspiring English sources

Thus, while mutating residues within the hypothetical pseudosubstrate site had no effect on Chk1 activation in the absence of damage, arguing against the pseudosubstrate hypothesis, mutation of D469 did compromise function in the presence of DNA damage indicating that the highly conserved aspartic acid at that position is important for Chk1 function in the DNA damage checkpoint pathway.

Moreover, the approximately 45% reduction in glucose or oxygen consumption with anesthesia-induced loss of consciousness is compatible with the idea that the neuronal energy budget is limiting in the conscious state, such that decreases may compromise function, leading to blackened vision, fainting, and ultimately causing unconsciousness [56].

Human bites in the maxillofacial region compromise function and aesthetics, resulting in social and psychological effects.

Xerostomia has significant physical, social and psychological consequences which compromise function and quality of life.

Other missense mutations might only partially compromise function and behave as risk alleles [ 29].

Secondary musculoskeletal impairments such as contracture, deformity, and osteoporosis can occur and further compromise function.

Children like adults are also prone for various oral disorders, all of which can likely compromise functioning, well-being and QoL [ 17].

These data highlight the need for a range of functional studies to be performed in order to identify variants with partially compromised function.

Alternatively, the surgeon might elect to perform a more proximal lower extremity amputation, which will allow better soft tissue coverage but compromises function of the lower extremity.

Routine culture of primary hepatocytes is difficult and cumbersome due to their ability to develop compromised function.

However, it is not known which of these proteins shows compromised function that may play a key pathogenic role.