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Li, X., Liu, X. & Yu, S. Psychological Stress-Derived Prolactin Modulates Occludin Expression in Vaginal Epithelial Cells to Compromise Barrier Function.
Chemical Peels and Lasers Compromise "Barrier Function"?
(B ) An excess of NTRs does not compromise barrier function.
In line with this concept, it was shown recently that the pro-inflammatory cytokines interleukin-4 (IL-4), IL-31, and TNF-α compromise barrier function (11) and modulate the expression of differentiation-associated proteins in keratinocytes (12– 12).
Collectively, the study supports the concept that the intestinal epithelium maintains a physiological state of inflammation with respect to continuous microbial exposure, which serves to maintain a tight intestinal barrier, without engendering overt inflammatory responses that would compromise barrier function.
Together, these data suggest that bronchial epithelial cells in smokers experience environmental stimuli (IL1B and oxidative stress) that may compromise barrier function, and respond with increased expression of various tight junction proteins.
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2, 3 Acute toxic liver injury leads to widespread hepatocyte necrosis and compromises barrier function.
A direct link between a compromised barrier function and allergy has been supported by recent findings in atopic dermatitis.
Infection with HIV-1 results in marked immunologic insults and structural damage to the intestinal mucosa, including compromised barrier function.
Surprisingly, however, genetic deletion of EC JAM-C did not affect tumor leukocyte infiltration or extent of tumor vascularity but led to the formation of tumor blood vessels with defective pericyte coverage and compromised barrier function.
Recently, a deletion of 2 late cornified envelope (LCE) genes within epidermal differentiation complex on chromosome 1 was shown to be enriched in 1426 patients with PsV, suggesting compromised barrier function in deletion carriers.
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