Sentence examples for compromise activity from inspiring English sources
Replacement of the nitrogen at N3 by an oxygen atom (compound 11, Table 1) would be predicted to lock the tautomeric forms of the scaffold and compromise activity through an unfavourable electrostatic clash with the carboxylic acid moiety of Glu308.
While the direct correlation of clinical severity with catalytic activity or thermostability of CdLS HDAC8 mutations is challenging, it is clear that the clinical phenotype is very sensitive to mutations that even slightly compromise activity or thermostability.
Both inhibition and overexpression of miR-134 and Pum2 compromise activity-dependent dendritogenesis.
In the latter circumstance, biases may be introduced that impair our understanding of the true epidemiology of TB and compromise activities that rely on accurate data.
The consequential alteration in the hepatocellular SAM to SAH ratio can compromise activities of many methyltransferases, including protein isoaspartyl methyltransferase (PIMT), to result in an accumulation of damaged proteins bearing isoaspartate residues [9,17 20].
However, liposomes designed to achieve good stability during the delivery phase often have compromised activity at the target site.
A conserved juxtamembrane domain harbours disease mutations, which compromised activity in GtrB in vitro and in human DPM1 tested in zebrafish.
The reduced binding affinity to H3K27me3 in vitro suggests that LHP1-CD* could have compromised activity in vivo.
All mutants deacylated D-Tyr-tRNATyr as efficiently as the wild type PfDTD, except S87A that showed partly compromised activity.
In vitro polyadenylation assays revealed severely compromised activity by the mutated protein, which generated only short oligo(A) extensions on RNA substrates, irrespective of RNA secondary structure.
In contrast, the mutant mtPAP showed severely compromised activity, where the extension achieved on either template, with or without oligo(A8), was only 5 10 nt (RNA14 shown in Fig. 4B lanes 3 and 7).
