They comprise hypotheses based on monoaminergic deficiency, hypothalamic-pituitary-adrenal (HPA) axis dysregulation, neurogenetic-neurotrophic-growth factor impairment, metabolic disturbances, circadian rhythm desynchronization, and inappropriate stimulation of the immune system [ 18– 23, 23– 26].
The 61 subsequent FieldREG applications reported here comprise 21 hypothesis-based formal replications, along with 40 further explorations designed to learn more about the circumstances that favor anomalous deviations.
The implications of these findings and whether the detection of subclinical myocardial necrosis truly represents ongoing myocardial damage that can be averted by more globally aggressive preventive efforts reducing future MACE risk comprise a hypothesis that needs further testing by a biomarker-guided therapeutic approach.
Shaping hypotheses comprises: "… refining the definition of the construct and building evidence which measures the construct in each case" (Eisenhardt 1989: 541).
Additionally, we introduced four structures that comprised the various hypotheses.
Based on Fung's transparency action cycle, all of these hypotheses comprise the framework of our research, which is illustrated in Figure 1.
They also contended that different combinations of genes and/or morphological characters likewise comprise independent phylogenetic hypotheses, because of the possibility of signal enhancement (sensu [ 34]).
The secondary hypotheses comprise the assumptions that CBT offers a specific advantage and is significantly more effective than SH, as demonstrated by a significantly greater improvement in HRQoL compared with SH groups at the one-year follow-up.
In this review, we propose a coherent, interoperable platform comprising knowledge engineering and hypothesis generation components for rapidly making determinations of confidence in mechanism and safety (among other goals) using experimental data and expert knowledge.
This theory comprises a set of hypotheses showing the influence of global climatic shifts and the subsequent environmental changes on the turnover of species assemblages as a result of the drifting of geographic distributions, lineage originations and extinctions.
