These studies reveal that the UBP deubiquitinating enzymes exhibit a conserved three-domain architecture, comprising Fingers, Palm, and Thumb.
The intestinal cells have a brush border on their apical side, comprising finger-like microvilli attached to a terminal web of actin and intermediate filaments (Troemel et al, 2008).
The first generation comprises finger-type membranes and two new mechanical designs use either additional edge welded bellows or a special corrugated Pd/Ag membrane.
It consists of different domains, including two zinc finger motifs comprising the RING finger, a B-box, a coiled-coil region (CC), and a C-terminal B30.2 domain (PRY/SPRY) [ 20] (Fig. 1).
It is demonstrated that a significant leachate mound can be expected to develop over time when the leachate collection system is comprised of finger drains; however the rate of increase and the magnitude at a given time will depend on a number of factors including the grainsize, thickness and spacing of the finger drains, and the thickness of waste as well as the leachate generation rate.
They share a highly conserved zinc finger DNA-binding domain comprising three zinc fingers at the C-terminus (ZNF), the adjacent Buttonhead-box (Btd-box: CXCPXC), and the N-terminal Sp-box, a stretch of conserved amino acids (SPLALLAATCSK/RIG/E) of unknown function.
The parkin gene contains an N-terminal ubiquitin-like domain and a C-terminal RING domain comprising two RING finger motifs [ 5].
14 The protein Trim17 is a member of the TRIM family that is defined by the presence of the tripartite motif (or RBCC), comprising a RING finger domain, one or two B-boxes and an associated coiled-coil domain.
These regions of H-bonding, together with the ion-mediated network, comprise the "fingers" of the polar interaction network, while W5 mediates hydrogen bonding between Arg16 and the carbonyl oxygen of the amide linker of dU14 (Fig. 6c), representing the thumb.
