We consider a complex economical objective that accounts for the total operational costs comprising a cost of consumed diluant, costs related to duration of processing, and a cost of product loss.
The first part comprises cost components and health care utilization items that occur regularly and tend to be relatively unimportant to the patient.
The key output in cost-benefit analyses is net costs, comprising the costs of SFM minus costs saved from the reduction in downstream health services utilisation.
Total 1-year, plan-wide costs (comprising screening costs, follow-up services costs, and breast cancer treatment costs) are calculated for the FFDM and FFDM + DBT scenarios, respectively.
The total costs, comprising operating costs (freshwater, wastewater treatment, pumping) and investment costs (piping, holding tanks), are minimised for a given time horizon.
The third category comprises cost-sensitive learning approaches that consider a different cost for the misclassification of each class [12, 13].
Indirect costs comprise costs of illness-related absenteeism from paid work (short- and long-term absence from work) as well as from unpaid work (e.g. housework), and costs of productivity loss or gain due to morbidity or premature mortality.
8 Evidence suggests that spasticity-related costs generally comprise costs of conventional treatment, including, but not limited to, hospitalization, rehabilitative therapy, and pharmacotherapy costs.
Structural costs comprise costs of additional co-ordination between institutes, interdisciplinary meetings, fortnightly patient discussions, training of new personnel, refresh training of old personnel, communication and monitoring.
In Finland, biologics administered by patients themselves are reimbursed by the FSII and thus do not comprise costs to a tertiary-level clinic.
