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The Flexible adaptation planning process (WSCapp), comprising change propagation – especially how positive and negative impacts propagate in an urban environment, can be used by those concerned with urban planning and urban adaptation to identify "where" the flexible adaptation responses can be implemented.
18 Our main endpoint, MCII, is clinically relevant to the patient, comprising change in the WOMAC function subscale and VAS pain measurement, both recognised validated endpoint measures.
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The approval of idursulfase was based on data from the pivotal clinical trial, which demonstrated that 1 year of weekly infusions of 0.5 mg/kg significantly improved the primary endpoint, a composite comprising changes in distance walked in 6 min and changes in percent-predicted forced vital capacity (FVC) compared to placebo [ 25].
Secondary outcomes comprised change in erythema measurements using a Mexameter (® MX 18) [ 27]; change in Trans Epidermal Water Loss TEWLL) using an Aquaflux (AF200) [ 28], and change in skin surface pH (using a pH meter).
Metamorphism comprises changes both in mineralogy and in the fabric of the original rock.
In forests, light is broadly recognised as one of the major factors determining growth, and morphological responses comprise changes in crown architecture and stem stature.
When a critical density of bacteria is reached, intra- and inter-bacterial species cross-talk begins through a process commonly referred to as quorum sensing, which comprises changes in gene expression and post-translational modification of proteins that ultimately lead to expression of the biofilm phenotype [22], [23].
Secondary outcomes will comprise changes in the severity of self-reported anxiety and insomnia symptoms respectively.
These comprised changes in both open-reading frames (ORFs) and untranslated regions (UTRs) of transcripts.
The first contribution category comprises changes in the involved and linked actors that are related to the activities of research.
The safety evaluation comprised changes in vital signs and laboratory parameters as well as the documentation/reporting of adverse events.
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