Amino acids are encoded by the full set of 64 triplet combinations of the four nucleic acids that comprise the backbone of DNA.
Corticosteroids comprise the backbone of asthma therapy and act to reduce inflammation through both gene activation and suppression 43.
Ontologies now comprise the backbone of biomedical informatics, with dedicated institutions such as the National Center for Biomedical Ontology (NCBO) [ 30] and resources such as the BioPortal [ 31].
Seven Cδ domains comprise the backbone of many bony fish delta chains, wherein a wide range of domain organization within fish lineages is observed.
The number of ORFs, which comprised the backbone sequence of Shigella spp. strains used in this study, was 1955 (include 12 ORFs which were not present in MG1655), which was less than the number cited in previous reports [ 10, 12].
Likewise, one of five disulfide bonds is flanking a catalytic triad (formed by S225, H528, D492) and the oxyanion hole comprising the backbone amide nitrogen atoms of G132 and E226 (Fig. 1c 24.
Recently, we reported on a series of short amphipathic α-helical peptides, comprising the backbone sequence (LLKK 2, with the ability to kill susceptible and drug-resistant Mycobacterium tuberculosis.
Based on the above evidence, it can be deduced that the β-sheet comprises the skeleton and backbone of the enzyme, while the α-helices or other secondary structure elements, e.g. turns, are required for the catalytic reaction.
