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The fourth block of the framework comprises studies that use economic indicators such as employment, income, output and GDP growth, as summarised in Table 6.
Based on our experience, we recommend a translational research approach that comprises studies on appropriate animal models and freshly collected primary cells from CF patients to develop a strong pre-clinical rationale before evaluating drugs in the clinic.
The fifth phase (broad validation) comprises studies that test the findings of hypothesis-testing studies in samples of people who differ from those who previously participated.
The second set comprises studies of prostate cancer incidence or mortality among workers involved in the production or use of herbicides potentially contaminated by TCDD.
Much of the existing literature comprises studies on perinatal outcomes after a previous live birth and suggests that short interpregnancy intervals are detrimental to maternal and perinatal wellbeing.
The fourth phase (narrow validation) comprises studies that attempt to validate the findings of hypothesis-testing studies in samples of people who are independent from, but similar to, those who participated in the hypothesis-testing phase.
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These priorities comprise studies of good sound environments and assessment methods for noise annoyance in multi-source environments.
The next level of the hierarchy comprised studies that used models for validation, including animal models [11 13] and mechanical experiments.
Baseline and follow-up assessments comprise study-specific structured, CATIs.
Typical analyses comprise studying vertex degrees or the paths between vertices.
This comprises experimental studies and investigations in natural systems.
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