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First, we performed comparisons between Tanner stages 1 and 5, which comprised the largest sample sizes.
Nevertheless the number of subjects included in this part of the analysis comprised the largest sample of all.
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Here, we chose the brain tissue class as reference, since it comprised the largest numbers of samples in all four data sets (Additional file 1 - Table S2) and also yielded large numbers of over-expressed genes.
A first merit lies in the size of the study population, which comprises the largest population-based sample (more than 6000 individuals) reported thus far.
From at least 15 cancer methylomes generated so far, the breast cancer methylome comprises the largest number of samples, followed by serous ovarian and kidney renal clear cell carcinoma (Table 1).
32– 34 However, these studies were small with the largest sample size comprising 126 dengue cases.
This series of 27 vulval samples comprises the largest systematic genome-wide analysis of vulval neoplasia performed to date.
Millennials comprise the largest cohort of freelancers.
Thus, MSPCR of R1 was chosen as the high throughput method for investigating the methylation status of the ACSL3 5'-CGI in the larger sample comprised of 56 children.
The main strength of this study was the nationwide consecutive patient registries, the contemporary data collection, the large sample comprising nearly 10,000 patients, the assessment of important clinical outcomes, and the use of pharmacy dispensations and not prescriptions alone, i.e., with the latter better reflecting true as opposed to intended drug use.
The large sample size comprising data from eight European countries, the strictly standardized data assessment, documentation and data cleaning processing, guarantee the highest possible data quality.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com