For this purpose, two thirds of the spectra, comprised of a representative proportion of tumour and normal spectra, were randomly assigned to a training dataset, with the remaining third being used as an independent test dataset.
The RICE Doppler spectrum is comprised of a LOS component and numerous scattering echo waves.
Sequencing studies of the mutational landscape of colorectal cancer revealed that the mutational spectrum is comprised of a limited number of frequently mutated genes and a large number of infrequently mutated genes [ 10].
The Spectrum computer package is comprised of a number of modules.
The prostate is comprised of a functional secretory epithelium, a basal epithelium, and a supporting stroma comprised of structural elements, and a spectrum of cell types that includes smooth muscle cells, fibroblasts, and inflammatory cells.
Several authors previously reported that the species N. transvalensis in fact comprises of an heterogeneous spectrum of organisms including both amikacin-susceptible and amikacin-resistant organisms, a hallmark of the N. transvalensis complex also incorporating the two newly described reported N. blacklockiae and N. wallacei [ 20].
Predictive models comprised of MIR spectra resulted in a RMSEC average of 0.13 regardless of the spectral transformations selected, and calibration R 2 values between 0.82 ± 0.01 and 0.85 ± 0.02 (Table 2, and Additional file 1: Table S3).
With this approach, a training set comprised of mass spectra and H-NMR spectra from urine derived from either unaffected individuals or patients with IC is employed so that the most fit combination of relative, normalized intensity features defined at precise m/z or chemical shift values plotted in n-space can reliably distinguish the cohorts used in training.
Note that our patient population comprised of individuals with a broad spectrum of ages, races, and pathologies, which ranges from psychiatric disorders to brain tumors.
The samples ranged from 1-5 cm in length and width, 0.1-1.5 cm in thickness, comprised a spectrum of both benign and malignant tissue pathologies, and did not require any additional procedures or resection that affected the patient or surgical outcome.
