PfEMP1s, which along with being a major virulence determinant are also a major antigenic target of the host immune response, are encoded by the var genes, which comprise a highly variable family of 60 genes, located in six internal gene clusters and at the ends of the parasite's chromosomes in the subtelomeric regions.
Second, and perhaps more pressing, is the revelation that rickettsial species may be comprised of highly variable genomes, particularly across exceedingly divergent strains.
The cyclo-dipeptide that is central to the ETP motif comprises a highly variable amino acid in addition to the requisite tryptophan residue.
The major parasite virulence factor P. falciparum erythrocyte membrane protein 1 (PfEMP1) is embedded in these knob structures through a transmembrane helix and comprises a highly variable ectodomain and a semiconserved intracellular segment [acidic terminal segment (ATS)] anchoring the molecule to the host cell (6).
The expression of HIF-1α was very heterogeneous, most likely reflecting the fact that tumor microenvironment comprises areas of highly variable hypoxic and non-hypoxic regions.
The highly variable G protein of HRSV comprises 298 [42] or 318 [43] residues.
First, the highly variable N-terminal A/B domain comprises a ligand-independent activation function (AF-1).
Taken collectively, these observations yield the manner in which the rickettsial genomes have acquired their variation: a conserved core genome is supplemented with a highly variable accessory genome that is comprised of gene decay and many horizontally acquired genes.
However, BF and TBRT (comprising RT and MT) must be considered as highly variable among individuals and more importantly, influenced by numerous pathologies.
It is notable that most of the newly identified Ss-LrpB binding sites that are directly bound, both in vitro and in vivo, are located in a highly variable region of the genome comprising multiple insertion sequence (IS) elements.
Spatial patterns in H. decipiens biomass following monsoon conditions were highly variable within a landscape that largely comprised potential seagrass habitat.
