The incidence and rates of hypoglycaemia and occurrence of adverse events were analysed in the safety population, comprising all treated patients.
The study included a reference arm comprising patients treated with an optimized dose of OROS-MPH, but the study was not powered to make inferential statistical comparisons between LDX and OROS-MPH.
Eligible women comprise those treated (11.5%), not requiring treatment (65%) and those having investigation (e.g. biopsy) but no further treatment (23.5%).
In fact, it has been extensively reported that patients in renal replacement therapy develop a complex disease comprising partially treated uremia and ill effects of dialysis, such as fluctuation in the extracellular fluid volume, residual inorganic ion disturbances and exposure to bioincompatible materials [ 7, 8].
Lower prevalence of WCH was also found in a massive multicenter study in Spain, comprising 12,895 treated hypertensive patients, of whom 2,772 had type 2 diabetes.
As a result, 245 patients were included, comprising 128 treated at MSKCC and 117 at AMC. Patient characteristics were not different between MSKCC and AMC, except for older age at MSKCC (mean age 65 vs. 61, respectively).
The patient population comprised 18 patients treated with a combination of cisplatin, adriamycin and cyclophosphamide (PACe) and 2 patients treated with chlorambucil.
Participants comprise consecutive adults treated with long-term in-center hemodialysis.
These 4 subgroups merged to comprise a control (historical controls treated before GENESIS and RB not achieved after GENESIS) group and treatment (patients treated after GENESIS and RB achieved after GENESIS) group for comparison.
Tests comprised four treated and control replicates for the VKPer strain and three replicates for the field-collected mosquitoes, set up on separate days using different mosquito batches.
