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The part of a sentence "comprise a large" is correct and usable in written English.
You can use it when referring to a group, amount, or range of something that is significant in size. Example: The new office complex comprises a large number of buildings spread across an expansive area.
Exact(59)
They also comprise a large proportion of the shelters' inhabitants.
African companies, many of which are small- or medium-sized enterprises, comprise a large percentage of total new alliance investments.
Scriptures comprise a large part of the literature of the world.
Note that the list and map count only JPMorgan's midtown Manhattan offices, which comprise a large portion of its work space.
In addition, PHA comprise a large class of polyester.
Unsurprisingly so, given that European hires comprise a large majority of its team.
Further, Muslims comprise a large segment of immigrants in Canada and in European countries.
The neural networks comprise a large number of highly interconnected elements called 'neurons'neurons
Maintenance, repairs and fuel comprise a large chunk of expenses over five-years time.
To represent these, individual-based models (IBMs) usually comprise a large number of submodels.
M1 aminopeptidases comprise a large family of biologically important zinc enzymes.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com