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Only the latest or most comprehensive sample size was included if studies had partly overlapping subjects.
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A comprehensive, updated sample size justification and statistical plan will be created together with an interim report after the interim analysis.
Strengths of our study are the robust sample size, comprehensive general population studied, not only a small set of young adults as seen in some seminal studies in the area (breslau and merikangas), migraine diagnosis were not self reported.
Because the di-peptide nitrogen source microarray was not comprehensive, the amino acid sample size was variable.
The strengths of this study are the large sample size, comprehensive assessment and bigger number of controls than the original ABCS 135 validation paper.
The strengths of this study included a large sample size, comprehensive analysis of each risk factors and endoscopic examination in all participants.
The manageable sample size facilitated comprehensive high confidence data linkages and total cohort follow-up using the PFD.
However, strengths of the study include using NHATS, a nationally representative longitudinal cohort, which provides us with a large sample size and comprehensive covariate-related questions.
While our study benefits from large sample size and comprehensive inclusion of all cases occurring in a large well-defined population there are some limitations that are noteworthy.
Duplicates: for studies published in more than one paper, the most comprehensive one reporting the largest sample size will be considered.
The strength of our study was the large sample size, the comprehensive analysis of several CMR factors, and the evaluation of preclinical signs of liver and cardiac abnormalities.
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