Sentence examples for comprehensive mutation from inspiring English sources

The first comprehensive mutation profiling of 623 genes in 188 adenocarcinomas identified 26 significantly mutated genes, including known oncogenes (KRAS, EGFR, ERBB2, ERBB4, EPHA3 and other ephrin receptor genes, KDR, and FGFR4) and tumor suppressor genes (TP53, CDKN2A, STK11, NF1, ATM, RB1, and APC) [ 7].

A new selection operator and a more comprehensive mutation operator are used.

We have analyzed a ribozyme catalyzing Diels-Alder cycloaddition reactions by comprehensive mutation analysis and a variety of probing techniques.

The entire BRCA1 coding sequence was amplified by PCR with primers especially designed for comprehensive mutation screening by single-strand conformation polymorphism (SSCP) analysis.

The purpose of this study was to validate the accuracy and sensitivity of our method for comprehensive mutation detection of hereditary hearing loss, and identify inherited mutations involved in human deafness accurately and economically.

Next-generation DNA sequencing provides an opportunity to provide carrier screening using more comprehensive mutation panels that are limited primarily by information about the clinical impact of detected sequence changes.

In this study, we performed a systematic exploration of the somatic mutations and their related features for cancer classification using a machine learning approach and the most comprehensive somatic mutation dataset so far.

Over the long term, the adaptation of new genomics technologies such as second generation sequencing may offer a unifying approach to comprehensive tumor mutation profiling.

Comprehensive ATM mutation screening of all coding exons and splice junctions has been carried out using the DOVAM-S [23], [24] method, which is comparable to sequencing for mutation detection.

This emphasizes the critical need to have knowledgeable end users to interpret the data as well as the necessity for more robust and comprehensive druggable mutation databases.

Taken together, these studies suggest that comprehensive somatic mutation screening and DNA content investigation of the mitochondrial genome may be a marker for tobacco smoke exposure and consequently for tobacco-related DNA damage and smoking-associated cancer risk.