Sentence examples for comprehensive interaction networks from inspiring English sources

To overcome this limitation, molecular features can be mapped into more comprehensive interaction networks, such as protein-protein or protein-DNA interaction networks, which can be much more comprehensive and unbiased, as well as disease and context specific.

For this reason, a comprehensive interaction network including all proteins that are expressed in a certain cell of interest has still not been published.

This allows InnateDB to expand on linear views of pathways to develop a more comprehensive interaction network perspective, highlighting potential cross-talk between pathways and/or prospective novel pathway members.

Here, the large-scale quantitative mapping of synthetic lethal interactions has reached genome-wide scale and the resulting comprehensive genetic interaction networks are a rich source for the functional annotation of genes [8,15].

We mapped the PPC value onto a comprehensive protein interaction network (PIN) to build a CePIN (see Methods).

To construct a comprehensive binary interaction network, we rank the observed co-complex interactions according to their BINM scores and predict the top-ranked interactions as binary interactions.

We present a comprehensive molecular interaction network for thyroid cancer (576 nodes and 3136 edges), and discuss its properties using standard network metrics.

The comprehensive physical interaction network in yeast is used to show that scale-space based measures consistently give superior performance when distinguishing protein functional categories and three major types of functional interactions genetic interaction, co-expression and perturbation interactions.

This study provides the most comprehensive protein interaction network map of the MICOS complex to date and will serve as a resource for further elucidation of MICOS assembly and regulation.

Although a large amount of ligand –target and target –target bioactivity data were provided from public data sources, including PubChem, 23 ChEMBL, 24 and BindingDB, 25 to our knowledge there are no databases or tools that utilize such data to provide comprehensive pharmacology interaction network analysis based on a user-defined interaction.

In a recent work, Sumazin et al integrated gene and miRNA expression data from sample-matched datasets and constructed a comprehensive miRNA gene interaction network, inferring that phosphatase and tensin homolog (PTEN) is a key regulator of gliomagenesis. 2 Integrating multiple types of data simultaneously can increase the precision of computational predictions.