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In contrast, leptospiral outer membrane proteins (OMPs) are generally well conserved [8], [9] and would have the potential advantage of inducing comprehensive immunity [10].
98 Potential advantages of this approach include the very low cost of production, the serotype-independent mechanisms of protection, and the possibility of conferring comprehensive immunity to colonization and invasive disease.
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Although C. elegans has no adaptive immune system, it has comprehensive systemic immunity.
The emerging picture from these studies is that corals are complex organisms as revealed by a diverse set of receptors and a comprehensive innate immunity reservoir which are important for responses to the environment [ 15].
To more clearly differentiate host protective from damaging immunity, comprehensive data sets at both the organ and the cell level are needed.
Current efforts are focused on making better BCG priming vaccines designed to induce a comprehensive and balanced immunity followed by booster(s) targeting a specific set of relevant antigens in common with the BCG prime.
Such an expansive view begins to build a more comprehensive picture of immunity as mediating both competitive and cooperative relationships, which are not captured in the laboratory setting where standard conditions frame experiments that only barely reflect the complexity of the environmental setting (Viney and Riley 2014, p. 16).
Here we provide experimental data to address this question by undertaking a comprehensive analysis of immunity, stress response and longevity phenotypes in several representative isolates of four nematode species within the same genus.
Vaccinations, when given at the most sensitive developmental years of childhood, help to promote comprehensive and capable immunity, enabling children to fight off certain diseases.
For successful cancer immunotherapy, comprehensive knowledge of antitumor immunity as a dynamic spatiotemporal process is required for each individual patient.
In parallel, we are producing more P. alecto specific reagents (real time PCR and antibodies) for a more comprehensive examination of innate immunity in different cell lines generated in this study.
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