Sentence examples for comprehensive fine from inspiring English sources

Here we describe a comprehensive fine mapping effort in the KLK3 gene based on resequence data across a region of chr19q13.33, surrounding rs2735839, a SNP previously associated with prostate cancer (Eeles et al. 2008; Kote-Jarai et al. 2008) and/or serum prostate-specific antigen (PSA) levels (Ahn et al. 2008).

A comprehensive fine mapping study of the region is therefore required that incorporates both SNPs and structural variation in order to identify the causal variant(s) before proceeding to functional studies aimed at understanding the mechanism by which the variants predispose to PsV, and whether these differ in any way from those predisposing to PsA.

Ensuring the production of public goods that are the result of mass selection thus entails a comprehensive fine-tuning of dominant intellectual property regulatory tools, reconsidering the existing flexibilities aimed at in situ biodiversity conservation within the strong paradigm.

Extensive experimental results demonstrate that WinOSS outperforms existing occupancy sensing techniques, and provides comprehensive fine-grained occupancy information (including occupancy detection, counting and tracking) in an accurate, reliable, cost-effective and non-intrusive manner.

Recently a comprehensive fine-mapping of the 9p21 region using the targeted sequencing and the reference panel from 1000 Genome project has been performed [ 28].

Interestingly, two comprehensive fine-mapping studies of this region in case-control samples have identified SNPs in the same haplotype block as rs4977574 (rs2891168 and rs10757278, shown in Figure 1) as most strongly associated with disease [ 1, 9].

To evaluate the role of genetic variants at the TERT– CLPTM1L region in endometrial cancer risk, we carried out comprehensive fine-mapping analyses of genotyped and imputed SNPs using a custom Illumina iSelect array which includes dense SNP coverage of this region.

To extend characterisation of T2D GWAS loci, the most comprehensive fine-mapping experiment requires an exhaustive catalogue of variation across the region and necessitates powerful methodology to integrate statistical evidence of association with regulatory and functional annotation to reflect our prior beliefs about the likely mechanisms through which variants will impact on disease risk.

Visitors to this small Southern city (metropolitan population: 570,000) are often struck by the gap between its reputation as an intellectual backwater and the reality of its cultural offerings: a nationally recognized symphony, a civic ballet, a comprehensive university fine arts department, two repertory theater companies and a small but state-of-the-art performance center.

It is based on the actual need of area service, with the core of family, youth, and the elderly to set up service projects and to provide professional, comprehensive and fine social service to all community residents".

HapMap provides a more comprehensive and fine-scale estimation of recombination rates using high density multi-point SNP data (average inter-SNP distance: 900 nucleotides).