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Combining trastuzumab and pertuzumab therefore provides a more comprehensive blockade of the HER signaling pathways, resulting in greater antitumor efficacy.
Pertuzumab plus trastuzumab provides a more comprehensive blockade of HER2 signalling than trastuzumab alone.
Combination of these two HER2-targeting agents provides a complementary and more comprehensive blockade of HER2 signaling and results in greater antitumor activity than either agent alone.
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The proposals in this book that have received attention are the authors' advocacy of a "comprehensive air and naval blockade of North Korea" and a more limited blockade against Syria, and the advice that we should promote secession in eastern Saudi Arabia (which is oil rich and Shiite).
Michot, J. M. et al. Immune-related adverse events with immune checkpoint blockade: a comprehensive review.
"We are trying to secure a comprehensive ceasefire and end the blockade — this is our priority now," he said in a terse statement to reporters Friday evening before slipping back behind closed doors.
This broad range of data will allow a comprehensive assessment of the potential benefits of aldosterone blockade on patient health status and costs.
Despite all the limitations, this is the most comprehensive analysis evaluating the safety and efficacy of dual blockade of the renin-angiotensin system.
Two of the areas that have been especially active over the past few years include the comprehensive immunologic profiling of cancer patients receiving so-called 'immune checkpoint blockade' therapies and the search for immune signatures in lung transplant recipients that track with resistance to CMV infection.
Initial biomarker discovery approaches aimed to understand the pharmacological effects of TNF blockade in the peripheral blood compartment by pharmacogenomics for a comprehensive understanding of the mode of action.
A more comprehensive understanding of the complex responses of stromal cells to VEGF-blockade might inform the design of improved anti-angiogenic agents.
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