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Comprehensive association analysis of APOE regulatory region polymorphisms in Alzheimer disease.
Despite the many studies that have shown positive associations, a comprehensive association between genetic risks and aspirin hypersensitivity has not yet been discovered.
In this study, we performed comprehensive association and interaction analyses for 32 single-nucleotide polymorphisms (SNPs) in CHRNA5/A3/B4 with smoking initiation (SI), smoking quantity (SQ), and smoking cessation (SC) in a Korean sample (N = 8,842).
To conduct a comprehensive association study on Sp4 gene with bipolar disorder in European Caucasian families, we selected ten SNPs which started from the site 5 kb upstream of human SP4 transcription start site and ended at the site 3 kb downstream of its transcription termination.
Since our current knowledge of trans-acting regulation may still be insufficient for comprehensive association studies [17], an adequate approach at this stage would be to focus on the identification of cis-regulatory genes that are heritable as a monogenic trait.
In this study, we tried to fill this gap by designing the REPET package for the comprehensive association of all the meta-data obtained for a given TE family: (i) the de novo consensus sequences, (ii) the TE features used to classify them, (iii) the all-by-all comparisons from which they were built, and (iv) the TE copies they identify on the chromosomes.
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ADAM systematically establishes comprehensive associations between AMP sequences and structures through structural folds and provides an easy access to view their relationships.
We thus present A Database of Anti-Microbial peptides (ADAM), which contains 7,007 unique sequences and 759 structures, to systematically establish comprehensive associations between AMP sequences and structures through structural folds and to provide an easy access to view their relationships.
Thereby, we unified these diverse lines of evidence into a comprehensive functional association network in P. infestans while simultaneously controlling quality (expressed by the associated LLS) and coverage of these predictions.
To our knowledge this is the most comprehensive genetic association study of arsenic metabolism to date.
In this light, a comprehensive gene association network governing angiogenesis is needed to aid rational anti-angiogenesis drug design.
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