Sentence examples for comprehensive alignment from inspiring English sources

Implementing a center-wide precision medicine strategy at a major cancer center is a true multidisciplinary effort and requires comprehensive alignment of a broad screening strategy with a clinical research enterprise that can use these data to accelerate development of new treatments.

Each STX gene query resulted in a comprehensive alignment that was submitted to a bootstrapped maximum-likelihood (ML) phylogenetic analysis [12], [13].

The more comprehensive alignment found in File S1 was used to calculate the scores but Figure 4 can illustrate the conservation pattern of the predicted SDPs within their sequence context and also the identity of the residues for each PAT.

Starting from a comprehensive alignment of genomic regions, Zhao and co-workers from the EFI have identified the epimerase activity, pathway context and biological role in osmoprotection of a structurally characterised enzyme of unknown function from P. bermudensis using a combination of virtual screening, metabolomics, transcriptomics and biochemical experiments [ 25 ].

A more comprehensive alignment is presented in the Supplementary Information and Guillemin et al. To obtain soluble stable recombinant human Bcl-B (Uniprot: Q9HD36) protein from E. coli fermentations for our structural studies, we mutated the cysteines 20 and 128 to serine and deleted 27 C-terminal residues in the predicted TM region.

(A more comprehensive alignment, including several typical plant SKP1-like proteins, is shown in [ Additional Figure 2].) Only two amino acids, not among the key residues predicted to be involved in binding an F-box domain (Huang et al. 2006), are different between PiSSK1 and PhSSK1, suggesting that an SSK1 orthologue is present in P. inflata.

The main parts of this nuclear gene tree [14] have nevertheless been supported in later studies based on far more comprehensive alignments [e.g. 17] and genome level characters like retroposon insertion and indel differences [18] [20].

NanoOK provides comprehensive alignment-based analysis of Nanopore reads through a simple, easy to use interface.

However, no single tool yet exists to provide comprehensive alignment-based quality control and error profile analysis something that is extremely important given the speed with which the platform is evolving.

In Additional file 1: Figures S2 to S6, we provide more comprehensive alignments, which include one representative of each genus and display their predicted secondary structure.

Comprehensive alignments have been provided by other researchers, which indicated three deletions and at least one insertion compared with previous GII.17 strains.